PRINCIPAL INVOLVEMENT OF CYCLOOXYGENASE-1-DERIVED PROSTAGLANDINS IN THE C-FOS EXPRESSION OF THE RAT HIND BRAIN FOLLOWING VISCERAL STIMULATION WITH ACETIC-ACID
H. Kusuhara et al., PRINCIPAL INVOLVEMENT OF CYCLOOXYGENASE-1-DERIVED PROSTAGLANDINS IN THE C-FOS EXPRESSION OF THE RAT HIND BRAIN FOLLOWING VISCERAL STIMULATION WITH ACETIC-ACID, Molecular brain research, 52(1), 1997, pp. 151-156
We investigated the relationship between c-fos expression in the hind
brain and peritoneal prostaglandin (PG) synthesis after visceronocicep
tive stimulation with acetic acid in rats. Time-course studies on the
mRNA expression for c-fos in the hind brain and cyclooxygenase (COX) i
soforms in the peritoneal cells, as well as on the peritoneal 6-keto-P
GF(1 alpha) accumulation, after stimulation indicated that COX-1 but n
ot COX-2 was responsible for the peritoneal synthesis of PGs which wer
e suggested to evoke c-fos expression in the hind brain. Pharmacologic
al experiments using mofezolac, a preferential inhibitor against COX-1
, and NS-398, a selective inhibitor against COX-2, confirmed the invol
vement of COX-1 derived PGs in the induction of c-fos expression in th
e hind brain following the noxious stimulation. (C) 1997 Elsevier Scie
nce B.V.