REGENERATION OF PERI-IMPLANT INFRABONY DEFECTS USING PERIOGLAS - A PILOT-STUDY IN RABBITS

PerioGlas is a silicate-based synthetic bone augmentation material tha t has been used to fill periodontal defects with bonding and integrati on to both soft tissue and bone. The purpose of this research was to d etermine the PerioGlas interface with titanium dental implants and bon e. Seven live rabbits were used; however, one rabbit was euthanized at 3 days as a result of a tibial fracture through the implant placement site. Each rabbit received four 3.3 X 8 mm Imtec titanium plasma-spra yed dental implants, two in each proximal tibia. One implant in each r abbit was placed in the standard fashion. Two implants in each rabbit had a surgically created defect adjacent to one side of the coronal as pect of the implant. The defect was subsequently filled with PerioGlas . One implant in each rabbit had a surgically created defect that was not filled with PerioGlas. The rabbits were sacrificed at 1, 2, 3, 6, 12, and 24 weeks. Each specimen was prepared for histologic viewing, y ielding a nondecalcified specimen demonstrating the interface of bone, implant, and PerioGlas. The results demonstrate peripheral formation of osteoid, followed by bone deposition within the defect from host (s urgical margin) bose, toward the implant. The new osteoid and bone for m around the PerioGlas particles. Newly formed trabeculae connect thes e areas of osteoid and new bone around the PerioGlas, interconnecting the PerioGlas particles. The new bone eventually reaches the implant, and osseointegration occurs with incorporation of the PerioGlas partic les.