TREATMENT OF CONVULSIVE STATUS EPILEPTICUS WITH PROPOFOL - CASE-REPORT

Introduction: Convulsive status epilepticus (CSE) refractory to treatm ent with benzodiazepines, phenobarbital, and phenytoin presents a chal lenge to pediatric emergency and critical care specialists. Prompt sei zure control mag prevent mortality and morbidity. Case: A nine-month-o ld girl with hereditary fructose intolerance had prolonged, refractory CSE. Her seizures promptly stopped after administration of propofol ( 3 mg/kg bolus followed by infusion of 100 mu g/kg/min). This dose resu lted in electroencephalographic burst suppression, She required endotr acheal intubation, invasive hemodynamic monitoring, and pressor suppor t. Discussion: This is the first pediatric case of prolonged, refracto ry CSE treated wilt propofol. The adult experience is reviewed. Propof ol should be used only in a setting where definitive airway control an d hemodynamic support if possible.