CHROMATOGRAPHIC BEHAVIOR OF THE CHROMIUM(III) COMPLEX OF 1-PHENYL-3-METHYL-4-BENZOYL-5-PYRAZOLONE

The separation of the two geometrical isomers of the chromium(III) com plex of 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone was carried out using acetonitrile-water (90:10, v/v) and n-hexane-tetrahydrofuran (70:30, v/v) as the mobile phases for an ODS column and a silica gel column, r espectively. Identification of the isomers was performed using a high- performance liquid chromatography-continuous flow fast atom bombardmen t-mass spectrometry system. It was found that the fac complex eluted f irst, followed by the mer complex on the ODS column. (C) 1997 Elsevier Science B.V.