PREDICTORS OF ADVERSE EVENTS AFTER THE ADMINISTRATION OF ACELLULAR AND WHOLE-CELL DIPHTHERIA-TETANUS-PERTUSSIS VACCINES

Recurrence of adverse events, the effect of sire of injection, and con current administration of oral polio vaccine (OPV) and hepatitis B vac cine (HBV) on reactogenicity were assessed in recipients of two acellu lar pertussis vaccines given in combination with diphtheria and tetanu s toxoids (DTaP), one whole-cell DTP vaccine (DTPwc) and one DT vaccin e during a double blind, randomized, controlled clinical trial. Local and systemic side reactions were more likely to recur after the admini stration of DTaP and DT compared with DTPwc, In all vaccine groups, in jection in the buttock was associated with a lower rate of common adve rse events compared with injection in the thigh, while simultaneous ad ministration of OPV and/or HBV did not increase the risk of onset of s ide reactions. Published by Elsevier Science Ltd.