CONFIRMATION OF OLEANDER POISONING BY HPLC MS

Citation
A. Tracqui et al., CONFIRMATION OF OLEANDER POISONING BY HPLC MS, International journal of legal medicine, 111(1), 1998, pp. 32-34
Citations number
19
Categorie Soggetti
Pathology
ISSN journal
09379827
Volume
111
Issue
1
Year of publication
1998
Pages
32 - 34
Database
ISI
SICI code
0937-9827(1998)111:1<32:COOPBH>2.0.ZU;2-5
Abstract
A non-fatal case of Nerium oleander (common oleander) self-poisoning i n a 45-year-old female is presented. Initial symptoms were-nausea and vomiting, abdominal pain, phosphenes, cardiovascular shock and sinus b radycardia, Blood and urine were assayed for oleandrin, the major card iac glycoside of N. oleander, using a highly specific HPLC/MS procedur e. The blood concentration of oleandrin at admission was 1.1 ng/ml. Th is is the first report of an oleander intoxication ascertained by the mass spectrometric identification of oleandrin in blood. HPLC/MS appea rs to be the method of choice for the forensic-toxicological investiga tion of poisonings by cardiac glycosides.