EFFECTS OF VITAMIN-E AND CIMETIDINE ON PERITONITIS-INDUCED LIPID-PEROXIDATION

To investigate the effects of acute fecal peritonitis on plasma and ti ssue lipid peroxidation and possible protective effects of vitamin E ( Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups w ere designated as: controls, peritonitis, Vit E and cimetidine. Plasma , liver, lung and kidney thiobarbituric acid reactive substances (TBAR S) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elev ation in liver TBARS; however, neither Vit E nor cimetidine was effect ive in preventing TBARS formation. Administration of Vit E and cimetid ine caused significant decrements from the peritonitis value in liver and lung CD levels.