STRUCTURALLY SIMPLIFIED ZARAGOZIC ACID (SQUALESTATIN) - STEREOSELECTIVE PREPARATION OF A 3,4-UNSUBSTITUTED DERIVATIVE

Authors
ITO H MATSUMOTO M YOSHIZAWA T TAKAO K KOBAYASHI S
Citation
H. Ito et al., STRUCTURALLY SIMPLIFIED ZARAGOZIC ACID (SQUALESTATIN) - STEREOSELECTIVE PREPARATION OF A 3,4-UNSUBSTITUTED DERIVATIVE, Tetrahedron letters, 38(52), 1997, pp. 9009-9012
Citations number
18
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
52
Year of publication
1997
Pages
9009 - 9012
Database
ISI
SICI code
0040-4039(1997)38:52<9009:SSZA(->2.0.ZU;2-U
Abstract
Stereoselective preparation of a structurally simplified 3,4-unsubstit uted zaragozic acid derivative war achieved starting from D-glucose. T he present approach involved the stereoselective addition of a vinyl G rignard reagent, selective cleavage of 1,2-diol, and regioselective ac ylation of the hydroxyl group at C-6. (C) 1997 Elsevier Science Ltd.