SOLID-PHASE SYNTHESIS OF 5-AMINOPYRAZOLES AND DERIVATIVES

Authors
WATSON SP WILSON RD JUDD DB RICHARDS SA
Citation
Sp. Watson et al., SOLID-PHASE SYNTHESIS OF 5-AMINOPYRAZOLES AND DERIVATIVES, Tetrahedron letters, 38(52), 1997, pp. 9065-9068
Citations number
6
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
52
Year of publication
1997
Pages
9065 - 9068
Database
ISI
SICI code
0040-4039(1997)38:52<9065:SSO5AD>2.0.ZU;2-Q
Abstract
The development of a novel solid phase synthesis of some 5-aminopyrazo les and derivatives is described. Reaction of hydrazines with solid su pported beta-keto-nitrile (1) affords 5-aminopyrazoles (2) the amino g roup of which is readily acylated or sulphonylated. Generation of the solid supported beta-keto-nitrile (1) is non trivial and represents a key step in the overall synthesis. (C) 1997 Elsevier Science Ltd.