ENANTIOSELECTIVE ALPHA-ALKYLATION OF PIPERIDINE VIA CHIRAL PERHYDROPYRIDO[2,1-B][1,3,4]-OXADIAZINONE - AN EASY ROUTE FOR THE SYNTHESIS OF BOTH ENANTIOMERS OF CONIINE

Authors
PANDEY G DAS P
Citation
G. Pandey et P. Das, ENANTIOSELECTIVE ALPHA-ALKYLATION OF PIPERIDINE VIA CHIRAL PERHYDROPYRIDO[2,1-B][1,3,4]-OXADIAZINONE - AN EASY ROUTE FOR THE SYNTHESIS OF BOTH ENANTIOMERS OF CONIINE, Tetrahedron letters, 38(52), 1997, pp. 9073-9076
Citations number
23
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
52
Year of publication
1997
Pages
9073 - 9076
Database
ISI
SICI code
0040-4039(1997)38:52<9073:EAOPVC>2.0.ZU;2-F
Abstract
Enantioselective direct alkylation of piperidine involving chiral perh ydropyrido [2,1-b] [1,3,4]-oxadiazinone using either form of mandelic acid as chiral auxiliary is reported. The application of the strategy is demonstrated by the synthesis of (R)- as well as (S)-coniine. (C) 1 997 Elsevier Science Ltd.