HELICOBACTER-PYLORI UNMASKED - THE COMPLETE GENOME SEQUENCE

The publication of the complete genome sequence of Helicobacter pylori and the computer analysis of the genes it contains represents an enor mous advance in H. pylori research. Besides providing an overview of H . pylori biology, the genome sequence will aid future research and rad ically alter the research process. In particular, it will enable a `to p down' approach whereby genes are investigated because of their simil arity to genes of known function in other organisms. Other advances in biotechnology will allow all H. pylori genes to be studied simultaneo usly, proteins to be identified quickly, and potential drug targets to be evaluated efficiently. Progress in H. pylori research should now b e rapid, and with the research interest and resources focused on it, H . pylori could become the paradigm for post-genomic research.