A new design for bone implants, the bottle brush, was recently present
ed in a pilot study on marrow cavities in the femur of rabbits. In thi
s study, the concept is further evaluated on a mini bottle brush. The
fixture, 5x7 mm, with an implant shaft made of CP-titanium and bristle
s of nylon coated with sputtered titanium, was inserted into the cance
llous bone of the medial femoral condyle in 15 adult rabbits. The tita
nium fixture was compared with a similar brush without the titanium sp
uttered surface. The animals were sacrificed after 4 months and the qu
antity and quality of bone integration were evaluated with pull-out te
sts and histological examination. In both parameters, the values were
significantly higher for the titanium-sputtered brushes, with removal
forces similar to titanium cylinders of the same size and with a bone-
to-metal contact area of about 50%.