HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS OF 1,1'-BINAPHTHYL-SUBSTITUTED ALPHA-AMINOISOBUTYRIC-ACID

The direct and indirect stereochemical resolution of the enantiomers o f free and N-protected (R,S)-2',1':1,2;1 '',2 -dinaphthcyclohepta-1,3- diene-6-amino-6-carboxylic acid (Bin) was achieved by high-performance liquid chromatographic methods. The direct separation was carried out on a beta-cyclodextrin-based chiral stationary phase, ChiraDex, and t he indirect resolution by applying pre-column derivatization with 2,3, 4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate. (C) 1997 Else vier Science B.V.