A CONVENIENT SYNTHESIS OF GLYCOSYLATED HYDANTOINS AS POTENTIAL ANTIVIRAL AGENTS

Authors
KHODAIR AI
Citation
Ai. Khodair, A CONVENIENT SYNTHESIS OF GLYCOSYLATED HYDANTOINS AS POTENTIAL ANTIVIRAL AGENTS, Phosphorus, sulfur and silicon and the related elements, 122, 1997, pp. 9-26
Citations number
15
Journal title
Phosphorus, sulfur and silicon and the related elements → ACNP
ISSN journal
10426507
Volume
122
Year of publication
1997
Pages
9 - 26
Database
ISI
SICI code
1042-6507(1997)122:<9:ACSOGH>2.0.ZU;2-3
Abstract
Reaction of 5-arylidene-2-thiohydantoins 3a-d with glycosyl halides 4a ,b under alkaline conditions gave the respective bisglycosylated deriv atives 5a-h. Deacetylation with ammonia in methanol caused a change of the S-glycosyl residue and gave the N-3 glycosylated analogues 7a-h. S-Glycosylation also occured when N-3 substituted hydantoins 9a-h were reacted.