SONODYNAMICALLY-INDUCED IN-VITRO CELL-DAMAGE ENHANCED BY ADRIAMYCIN

Sonodynamically-induced cell damage and active oxygen generation enhan ced by adriamycin (ADM) were compared in the same in vitro insonation set-up. Significant enhancement of the rates of both ultrasonically-in duced cell damage and nitroxide generation was demonstrated with 40-16 0 mu M ADM. Both rates correlated very well resulting in a correlation coefficient of more than 0.99. The enhancement of both rates was supp ressed by 10 mM histidine. These results are consistent with the hypot hesis that ultrasonically-generated active oxygen plays a major role i n the sonodynamically-induced cell damage enhanced by ADM, (C) 1997 El sevier Science Ireland Ltd.