ANTIANDROGENIC PHENOLIC CONSTITUENTS FROM DALBERGIA-COCHINCHINENSIS

Four new compounds, 9-hydroxy-6,7-dimethoxydalbergiquinol, 6-hydroxy-2 ,7-dimethoxy-neoflavene, 6,4'-dihydroxy-7-methoxyflavan and 2,2',5-tri hydroxy-4-methoxybenzophenone, in addition to eight known phenolic com pounds including 7-hydroxy-6-methoxyflavone, have been isolated from t he stems of Dalbergia cochinchinensis. Their structures were establish ed by spectroscopic techniques including one-and two-dimensional NMR m ethods. The first two compounds showed potent inhibitory activity towa rds 5 alpha-dihydrotestosterone (DHT) which binds with an androgen rec eptor to form a DHT-receptor complex that causes androgen-dependent di seases. (C) 1997 Elsevier Science Ltd.