K. Shiba et al., MAINTAINING GENETIC-CODE THROUGH ADAPTATIONS OF TRANSFER-RNA SYNTHETASES TO TAXONOMIC DOMAINS, Trends in biochemical sciences, 22(12), 1997, pp. 453-457
The universal genetic code is determined by the aminoacylation of tRNA
s. In spite of the universality of the code, there are barriers to ami
noacylation across taxonomic domains. These barriers are thought to co
rrelate with the co-segregation of sequences of synthetases and tRNAs
into distinct taxonomic domains. By contrast, we show here examples of
eukaryote-like synthetases that are found in certain prokaryotes. The
associated tRNAs have retained their prokaryote-like character in eac
h instance, Thus, co-segregation of domain-specific synthetases and tR
NAs does not always occur, Instead, synthetases make adaptations of tR
NA-protein contacts to cross taxonomic domains.