MODELING BIOCHEMICAL OSCILLATIONS AND CELLULAR RHYTHMS

The usefulness of theoretical models for the study of biological rhyth ms is illustrated by considering several examples of oscillations resu lting from different modes of cellular regulation, Considered in turn are oscillations resulting from the regulation of enzyme activity, rec eptor function, transport, and gene expression The generation of rhyth mic behaviour by these various types of regulation is exemplified, res pectively, by glycolytic oscillations in yeast cells, the periodic syn thesis of cyclic AMP in Dictyostelium amoebae, intracellular calcium o scillations, and circadian rhythms in Drosophila.