DE-NOVO FAMILIAL CAVERNOUS MALFORMATION PRESENTING WITH HEMORRHAGE 12.5 YEARS AFTER THE INITIAL HEMORRHAGIC ICTUS - NATURAL-HISTORY OF AN INFANTILE FORM

Cerebral cavernous malformations are congenital, non-neoplastic lesion s, but they are known for their potential for growth. De novo lesion g enesis is exceptional and occurs more commonly with the familial form of the disease. We report the case of a 13-year-old Caucasian boy with a positive family history, who underwent surgery for a left parietal hemorrhage during the 1 st year of life and who recently presented wit h a new hemorrhage in the left temporal lobe quite distant from the pr evious hematoma bed. Both hemorrhages were caused by cavernous malform ations. Sequential magnetic resonance scans prior to the recent presen tation failed to disclose the growth of the new lesion. We reviewed th e literature for mechanisms of new lesion formation.