IMPROVED OUTCOME OF YOUNG-CHILDREN ON NIGHTLY AUTOMATED PERITONEAL-DIALYSIS

We reviewed our center's experience with nightly automated peritoneal dialysis (APD) as maintenance renal replacement therapy (RRT) for infa nts and children under the age of 5 years and compared it with nationa l dialysis and transplant data, A retrospective chart review of 19 con secutive patients with the onset of endstage renal disease (ESRD) befo re 5 years of age (mean = 1.8 years) between June 1988 and June 1994 w as performed. All patients received nightly APD, supplemental feedings , calcitriol, erythropoietin, and 10 of 19 were on growth hormone (rhG H) therapy. The growth of our patients was maintained or improved duri ng the study period, with the 10 of 19 on rhGH gaining a mean of one s tandard deviation in height when followed for 2 years. Our school-age children were all in age-appropriate classes. There were no deaths in our group; the incidence of peritonitis was lower than in national dat a. We conclude that APD is a realistic option for the treatment of ESR D in the 0- to 5-year-old child. Because of the improved graft and pat ient survival in older children, APD in a specialized center might be the RRT of choice in this age group, allowing good growth and developm ent while maximizing the chances of an eventual and successful renal t ransplant.