We evaluated the effect of 2 years' therapy with an angiotensin conver
ting enzyme inhibitor (captopril) in 16 patients who had severe reflux
nephropathy and microalbuminuria, During the period of therapy, micro
albuminuria decreased, glomerular filtration rate measured by diethyle
netriamine pentaacetate scan, serum creatinine, and blood pressure rem
ained stable. We suggest the captopril was useful in reducing microalb
uminuria and may have slowed the progression of renal damage in our pa
tients.