ROLE OF THE ACTIN CYTOSKELETON IN ISCHEMIA-INDUCED CELL INJURY AND REPAIR

Authors
MOLITORIS BA LEISER J WAGNER MC
Citation
Ba. Molitoris et al., ROLE OF THE ACTIN CYTOSKELETON IN ISCHEMIA-INDUCED CELL INJURY AND REPAIR, Pediatric nephrology, 11(6), 1997, pp. 761-767
Citations number
95
Categorie Soggetti
Pediatrics,"Urology & Nephrology
Journal title
Pediatric nephrology
ISSN journal
0931041X → ACNP
Volume
11
Issue
6
Year of publication
1997
Pages
761 - 767
Database
ISI
SICI code
0931-041X(1997)11:6<761:ROTACI>2.0.ZU;2-7
Abstract
This paper reviews the role of the actin cytoskeleton in the establish ment and maintenance of surface membrane structure and function in all epithelial cells. It describes in detail certain interactions between the actin cytoskeleton and the surface membrane. Recent studies show that ischemia and/or ATP depletion will rapidly disrupt the actin cyto skeleton, an important event in ischemia-induced cell injury. Finally, the review examines specific functional and structural interactions b etween the actin cytoskeleton and the surface membrane.