CARBON-TETRACHLORIDE DOES NOT INDUCE MICRONUCLEUS IN EITHER MOUSE BONE-MARROW OR PERIPHERAL-BLOOD

We performed mouse bone marrow and peripheral blood micronucleus tests on carbon tetrachloride (CCl4). In the bone marrow assay, bone marrow cells were collected once after 24 h, and twice, with a 24-h interval at a dose of 500, 1000 and 2000 mg/kg. In the peripheral blood assay, blood samples were collected 0, 24, 48 and 72 h after a single intrap eritoneal injection at a dose of 1000, 2000 and 3000 mg/kg. As a resul t, micronucleated polychromatic erythrocytes (MNPCEs) were observed ne ither in the bone marrow assay nor the peripheral blood assay. We conc luded that CCl4 does not induce chromosomal aberrations in the mouse b one marrow cells under these experimental conditions. (C) 1997 Elsevie r Science B.V.