COMPARISON OF THE EFFECTS OF STANOZOLOL, OXYMETHOLONE, AND TESTOSTERONE CYPIONATE ON THE SEXUAL-BEHAVIOR OF CASTRATED MALE RATS

In 3 experiments, adult male Long-Evans rats were castrated and treate d daily with an anabolic-androgenic steroid (AAS) compound (either sta nozolol, oxymetholone, or testosterone cypionate) for 6 weeks. Subject s were assigned to 5 groups that received injections of a high, medium , or low dose of the AAS, testosterone propionate, or the oil vehicle. Stanozolol failed to maintain ejaculation at any dose tested. Althoug h some subjects receiving the low dose of oxymetholone ejaculated, oxy metholone generally failed to stimulate ejaculation above the levels o f the oil group. Testosterone cypionate sustained ejaculation at all d oses tested. The relative potency of the medium dose of each AAS in th e sex accessory tissues was (from most potent to least potent): testos terone cypionate > stanozolol = oxymetholone = oil. Thus, these 3 AAS compounds produced a range of behavioral and endocrine responses in ca strated male rats.