OBJECTIVE: To determine whether interval resection in asymptomatic pat
ients after 1 or 2 episodes of acute diverticulitis (prophylactic rese
ction) is justified as a means of preventing late inflammatory complic
ations of diverticular disease. DESIGN: A retrospective analysis. SETT
ING: A university-affiliated tertiary care hospital. PATIENTS: Those r
equiring hospitalization from 1987 to 1995 for treatment of acquired d
iverticular disease of the colon. Twenty-eight patients underwent elec
tive resection and 154 were treated for inflammatory complications (pe
rforation, fistula, complete large-bowel obstruction). INTERVENTIONS:
Standard surgical management for diverticular disease, but only 3 prop
hylactic resections were undertaken during this period. OUTCOME MEASUR
ES: Type of operation, stoma creation and closure, hospital death. In
those treated for complicated disease, the effects on outcome of all p
revious outpatient treatment and hospitalizations. RESULTS: Only 10% o
f those presenting with complications had been treated conservatively
for acute diverticulitis and only 5% had been hospitalized for this re
ason. CONCLUSIONS: Prophylactic resection is unlikely to prevent late
major complications of diverticular disease; therefore, as an elective
indication for surgery in this disease its use is questionable.