LIMITED WEGENER GRANULOMATOSIS WITH CENTRAL-NERVOUS-SYSTEM INVOLVEMENT AND FATAL OUTCOME

A 74-year-old woman was admitted to the medical department with vertig o and confusion, and suffered seizures three days later. Clinical, rad iological and histopathological examination revealed limited Wegener's granulomatosis (WG) with central nervous system (CNS) involvement. In itially she was treated successfully with prednisolone and cyclophosph amide, but she relapsed after 25 months and died four weeks later. Aut opsy showed widespread granulomas with vasculitis in the cerebrum. The se findings emphasize the importance of considering WG in CNS disease of unclear origin, and demonstrate the aggressive nature of the diseas e.