Objective: The purpose of this study was to determine the optimal timi
ng for placement and to evaluate short-and long-term outcomes of endos
seous implants in bone-grafted alveolar clefts. Design: Fourteen patie
nts who underwent alveolar cleft bone grafting (ACBG) and closure of a
n oronasal fistula followed by restoration of the missing lateral inci
sor tooth using endosseous implants (EI) were studied. The oronasal fi
stulae were closed using local flaps, and the alveolus was grafted wit
h fresh autogenous iliac marrow. Endosseous implants were placed a min
imum of 4 months following ACBG. The average age at ACBG was 20.35 yea
rs (range, 12-65 yr), and at implant placement 22.2 years (range, 15-6
6 yr). It was necessary to regraft the alveolar cleft region in six pa
tients to provide adequate bone volume for implant placement. Those wh
o required alveolar regrafting had an increased mean interval between
the initial ACBG and planned implant placement compared to the patient
s with adequate bone available for implant placement 26.4 months (rang
e, 4-46 mo) versus 15.75 months (range, 4-36 mo). Results: Twenty-nine
implants were placed in 14 patients, 9 outside of the cleft region an
d 20 in grafted alveolar clefts. Eighteen of 20 (90%) implants in the
bone-grafted alveolar clefts have been successfully restored. The mean
followup after implant placement was 39.1 months (range, 1-54 mo), an
d after restoration 28.5 months (range, 1-47 mo). Conclusions: Endosse
ous implants can be placed in bone-grafted alveolar clefts. Considerat
ion should be given to the adequacy of graft volume and ridge morpholo
gy at the time of ACBG. The interval between ACBG and implant placemen
t is important. The greater the interval beyond 4 months, the more lik
ely there will be inadequate bone volume to accept an implant.