INTERCELLULAR COMMUNICATION, TUMOR PROMOTION AND NONGENOTOXIC CARCINOGENESIS - RELATIONSHIPS BASED UPON STRUCTURAL CONSIDERATIONS

Authors
ROSENKRANZ M ROSENKRANZ HS KLOPMAN G
Citation
M. Rosenkranz et al., INTERCELLULAR COMMUNICATION, TUMOR PROMOTION AND NONGENOTOXIC CARCINOGENESIS - RELATIONSHIPS BASED UPON STRUCTURAL CONSIDERATIONS, Mutation research. Fundamental and molecular mechanisms of mutagenesis, 381(2), 1997, pp. 171-188
Citations number
96
Journal title
Mutation research. Fundamental and molecular mechanisms of mutagenesis
ISSN journal
13861964 → ACNP
Volume
381
Issue
2
Year of publication
1997
Pages
171 - 188
Database
ISI
SICI code
1386-1964(1997)381:2<171:ICTPAN>2.0.ZU;2-M
Abstract
An SAR model for inhibition of metabolic cooperation (iMC) was develop ed. The structural and physicochemical features associated with the ab ility to cause iMC are primarily lipophilic moieties consistent with t he possibility that they represent receptor-binding ligands. There are also significant parallels between the structural descriptors associa ted with iMC and those associated with tumor promotion and with carcin ogenesis in rodents. Overall, the present study provides structural ev idence that iMC is a feature associated with the carcinogenic process. (C) 1997 Elsevier Science B.V.