Increase in MD losses in vaccinated commercial pullet and layer flocks
has been observed since the end of 1993. Lymphoid rumours in the prov
entriculus, spleen and liver are the most pronounced macroscopic chang
es. The mortality rates vary according to the chicken lines between 0.
3 and 28.8%. Generally one commercial white leghorn strain was more fr
equently affected than another white one and a brown one. Vaccination
trials using Rispens strain either alone in single or double doses or
in combination with turkey herpesvirus vaccine (HVT), or even revaccin
ation has shown insufficient protection results in this white line. An
increase in the virulence of the MD field isolates or a decrease in t
he genetic resistance of chicken stocks are discussed as possible caus
es.