PLATELET-DERIVED GROWTH-FACTOR IN HUMAN BRAIN-TUMORS

Authors
KIRSCH M WILSON JC BLACK P
Citation
M. Kirsch et al., PLATELET-DERIVED GROWTH-FACTOR IN HUMAN BRAIN-TUMORS, Journal of neuro-oncology, 35(3), 1997, pp. 289-301
Citations number
102
Categorie Soggetti
Clinical Neurology",Oncology
Journal title
Journal of neuro-oncology → ACNP
ISSN journal
0167594X
Volume
35
Issue
3
Year of publication
1997
Pages
289 - 301
Database
ISI
SICI code
0167-594X(1997)35:3<289:PGIHB>2.0.ZU;2-Z
Abstract
This paper initially reviews ligand and receptor systems for the PDGF family and the signalling systems they use as well as their role in ne ural developments. It then describes the putative role of this family in astrocytoma, meningioma, and pituitary adenoma pathogenesis. Potent ial therapies with receptor antagonists or dominant negative mutants a re discussed in the final sections.