REVERSIBLE ACYLATION OF ELASTASE BY GAMMA-LACTAM ANALOGS OF BETA-LACTAM INHIBITORS

Authors
WESTWOOD NJ CLARIDGE TDW EDWARDS PN SCHOFIELD CJ
Citation
Nj. Westwood et al., REVERSIBLE ACYLATION OF ELASTASE BY GAMMA-LACTAM ANALOGS OF BETA-LACTAM INHIBITORS, Bioorganic & medicinal chemistry letters, 7(23), 1997, pp. 2973-2978
Citations number
26
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
23
Year of publication
1997
Pages
2973 - 2978
Database
ISI
SICI code
0960-894X(1997)7:23<2973:RAOEBG>2.0.ZU;2-M
Abstract
The reaction of a monocyclic gamma-lactam with the serine protease ela stase occurs via reversible formation of a hydrolytically labile acyl- enzyme complex; in contrast analogous beta-lactam inhibitors irreversi bly react to form a relatively stable acyl-enzyme complex. (C) 1997 El sevier Science Ltd.