SYNTHESIS AND CHARACTERIZATION OF A NOVEL RANITIDINE DIMER

Authors
FRUTOS RP ROTH GP
Citation
Rp. Frutos et Gp. Roth, SYNTHESIS AND CHARACTERIZATION OF A NOVEL RANITIDINE DIMER, Bioorganic & medicinal chemistry letters, 7(23), 1997, pp. 3045-3048
Citations number
7
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
23
Year of publication
1997
Pages
3045 - 3048
Database
ISI
SICI code
0960-894X(1997)7:23<3045:SACOAN>2.0.ZU;2-X
Abstract
A route towards the synthesis of a ranitidine bulk drug product impuri ty is described. This protocol involves acetyl chloride initiated oxon ium ion generation and subsequent trapping to form the corresponding r anitidine dimer (1). This synthesis allowed for structure verification of the impurity and provided reference supplies for further analytica l and toxicology investigations. (C) 1997 Elsevier Science Ltd.