SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL THF 1-BETA-METYLCARBAPENEMS - II

Authors
LIN YI BITHA P SAKYA SM LANG SA YANG YJ WEISS WJ PETERSEN PJ BUSH K TESTA RT
Citation
Yi. Lin et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL THF 1-BETA-METYLCARBAPENEMS - II, Bioorganic & medicinal chemistry letters, 7(23), 1997, pp. 3063-3068
Citations number
16
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
23
Year of publication
1997
Pages
3063 - 3068
Database
ISI
SICI code
0960-894X(1997)7:23<3063:SASONT>2.0.ZU;2-J
Abstract
Two series of active aminomethyl-THF 1 beta-methylcarbapenem derivativ es were synthesized. In general, they were all slightly less active th an their parent compounds and failed to demonstrate enhanced activity against P. aeruginosa. (C) 1997 Elsevier Science Ltd.