C-TERMINAL INCORPORATION OF ALPHA-TRIFLUOROMETHYL-SUBSTITUTED AMINO-ACIDS INTO PEPTIDES VIA IN-SITU DEPROTECTION OF N-TEOC DERIVATIVES

Authors
HOLLWECK W SEWALD N MICHEL T BURGER K
Citation
W. Hollweck et al., C-TERMINAL INCORPORATION OF ALPHA-TRIFLUOROMETHYL-SUBSTITUTED AMINO-ACIDS INTO PEPTIDES VIA IN-SITU DEPROTECTION OF N-TEOC DERIVATIVES, Liebigs Annalen, (12), 1997, pp. 2549-2551
Citations number
20
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
12
Year of publication
1997
Pages
2549 - 2551
Database
ISI
SICI code
0947-3440(1997):12<2549:CIOAA>2.0.ZU;2-A
Abstract
A new method for peptide coupling, involving alpha-trifluoromethyl sub stituted amino acids as nucleophiles, proceeds via fluoride catalyzed in situ deprotection and coupling of N-Teoc protected amino acid ester s. A mixed anhydride is thought to be the reaction intermediate.