AMIDINE-INDUCED RING TRANSFORMATION OF A SUBSTITUTED 1,1-DIOXO-1,2-THIAZINE-4-CARBALDEHYDE INTO NEW PYRIMIDINE-DERIVATIVES

Authors
FANGHANEL E BARTOSSEK H BAUMEISTER U HARTUNG H
Citation
E. Fanghanel et al., AMIDINE-INDUCED RING TRANSFORMATION OF A SUBSTITUTED 1,1-DIOXO-1,2-THIAZINE-4-CARBALDEHYDE INTO NEW PYRIMIDINE-DERIVATIVES, Liebigs Annalen, (12), 1997, pp. 2617-2620
Citations number
27
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
12
Year of publication
1997
Pages
2617 - 2620
Database
ISI
SICI code
0947-3440(1997):12<2617:ARTOAS>2.0.ZU;2-K
Abstract
As a masked 1,3-dicarbonyl compound, the 1,1-dioxo-2H-1,2-thiazine-4-c arbaldehyde 1 undergoes ring transformation with amidines to produce 2 -substituted -methylthio-2-(N-phenylsulfamoyl)vinyl]pyrimidines 3a-f. For 3b, an X-ray structure analysis is reported. From the 2-methylthio -2-(N-phenylsulfamoyl)vinyl]pyrimidine (3e), the substituted pyrimidin one 4 is obtained by acidic hydrolysis.