SIRDALUD IN THE TREATMENT OF PAINFUL MUSC ULOTONIC SYNDROME

The paper considers mechanisms of action and clinical efficacy of the drug sirdalud (tizanidine) in painful musculotonic syndromes. Sirdalud is an agonist of alpha(2)-adrenergic receptors effective in painful m usculotonic syndromes and spasticity of various genesis. The drug exhi bits myorelaxative and direct central analgetic effects, is well toler ated and has minimal side effects (drowsiness). The response can be se en as early as the first treatment days. Sirdalud is applicable as alo ne and in combination with non-steroid antiinflammatory drugs.