BIOCHEMICAL-ALTERATIONS IN NEONATAL HYPOXIC-ISCHEMIC BRAIN-DAMAGE

Authors
GUCUYENER K GUR T OZ E TURKYILMAZ C OZTURK G ERBAS D ATALAY Y HASANOGLU A
Citation
K. Gucuyener et al., BIOCHEMICAL-ALTERATIONS IN NEONATAL HYPOXIC-ISCHEMIC BRAIN-DAMAGE, Prostaglandins, leukotrienes and essential fatty acids, 57(6), 1997, pp. 567-570
Citations number
21
Categorie Soggetti
Cell Biology",Biology,"Endocrynology & Metabolism
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
57
Issue
6
Year of publication
1997
Pages
567 - 570
Database
ISI
SICI code
0952-3278(1997)57:6<567:BINHB>2.0.ZU;2-Q
Abstract
Asphyxiated (n = 39) and control (n = 23) were elected for the study. Free radical-mediated lipid peroxidation, prostaglandin E-2 and vitami n E levels were studied and the degree of hypoxic ischaemic encephalop athy was determined in each case. In the hypoxic group the concentrati on of prostaglandin E-2 activity (P < 0.05) and malondialdehyde levels (P < 0.01) were significantly higher when compared to that of control s. The high vitamin E concentrations in the asphyxiated infants suppor ts the role of oxygen free radicals in hypoxic ischaemic encephalopath y of newborns.