INHIBITION OF FUCOSYL-TRANSFERASE AND FUCOSIDASE BY A RIGID BICYCLIC MIMIC OF ALPHA-L-FUCOSE

Authors
BEACHAM AR SMELT KH BIGGADIKE K BRITTEN CJ HACKETT L WINCHESTER BG NASH RJ GRIFFITHS RC FLEET GWJ
Citation
Ar. Beacham et al., INHIBITION OF FUCOSYL-TRANSFERASE AND FUCOSIDASE BY A RIGID BICYCLIC MIMIC OF ALPHA-L-FUCOSE, Tetrahedron letters, 39(1-2), 1998, pp. 151-154
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
1-2
Year of publication
1998
Pages
151 - 154
Database
ISI
SICI code
0040-4039(1998)39:1-2<151:IOFAFB>2.0.ZU;2-B
Abstract
A rigid bicyclic analogue of a-L-fucose, prepared from a monoacetonide of L-gulonolactone in an overall yield of 36% without the need for co lumn chromatography, is a potent inhibitor of fucosidases and a weak i nhibitor of a fucosyl transferase. (C) 1997 Elsevier Science Ltd. All rights reserved.