SYNTHESIS OF GINSENOSIDE RG(3), A MINOR CONSTITUENT OF GINSENG RADIX

Authors
ANUFRIEV VP MALINOVSKAYA GV DENISENKO VA UVAROVA NI ELYAKOV GB KIM SI BAEK NI
Citation
Vp. Anufriev et al., SYNTHESIS OF GINSENOSIDE RG(3), A MINOR CONSTITUENT OF GINSENG RADIX, Carbohydrate research, 304(2), 1997, pp. 179-182
Citations number
10
Categorie Soggetti
Chemistry Applied","Chemistry Inorganic & Nuclear",Biology
Journal title
Carbohydrate research → ACNP
ISSN journal
00086215
Volume
304
Issue
2
Year of publication
1997
Pages
179 - 182
Database
ISI
SICI code
0008-6215(1997)304:2<179:SOGRAM>2.0.ZU;2-5
Abstract
Glycosylation of 12 beta-acetoxy-dammar-24-en-3 beta,20(S)-diol (4), w ith hepta-O-acetyl-alpha-sophorosyl bromide (5) under catalysis by Ag2 CO3 or Ag2O afforded a chromatographically unseparated mixture of the alpha-and beta-linked octaacetates 6 and 7 in an approximately 2.5:1 r atio. After deprotection and chromatographic purification, the free al pha- (8) and beta-glycosides (9) were obtained. Sophoroside 9 was iden tical in all respects with ginsenoside Rg(3), the minor component of G inseng Radix rubra. All compounds were fully characterized by H-1 and C-13 NMR spectroscopy, (C) 1997 Elsevier Science Ltd. All rights reser ved.