THE MITOCHONDRIAL TRNA(LEU(UUR))A TO G-3243 MUTATION IS ASSOCIATED WITH INSULIN-DEPENDENT AND NON-INSULIN-DEPENDENT DIABETES IN A CHINESE POPULATION

Citation
Pr. Smith et al., THE MITOCHONDRIAL TRNA(LEU(UUR))A TO G-3243 MUTATION IS ASSOCIATED WITH INSULIN-DEPENDENT AND NON-INSULIN-DEPENDENT DIABETES IN A CHINESE POPULATION, Diabetic medicine, 14(12), 1997, pp. 1026-1031
Citations number
42
Categorie Soggetti
Endocrynology & Metabolism
Journal title
ISSN journal
07423071
Volume
14
Issue
12
Year of publication
1997
Pages
1026 - 1031
Database
ISI
SICI code
0742-3071(1997)14:12<1026:TMTTGM>2.0.ZU;2-S
Abstract
The mitochondrial DNA tRNA(Leu(UUR)) A to G 3243 mutation is associate d with maternally inherited diabetes in Caucasians and Japanese. In a Hong Kong Chinese population we have detected the 3243 mutation in 2 o f 74 unrelated subjects with well characterized insulin-dependent (Typ e 1) diabetes mellitus (IDDM) and 2 of 75 unrelated subjects with youn g onset (<35 years) non-insulin-dependent diabetes (NIDDM). The 3243 m utation has only previously been associated with IDDM in Japanese. Rac ial differences in association of the mitochondrial 3243 mutation with IDDM suggest the influence of other genes that may increase its diabe togenic pathogenicity in Oriental races. We also found a significant e xcess of maternal inheritance of diabetes in the young onset NIDDM coh ort, with a ratio of diabetic mothers to fathers of 2.4:1, p< 0.005. T he 3243 mutation, however, only accounts for a small proportion of the observed excess maternal inheritance, and further study is needed to search for other diabetes associated mitochondrial DNA mutations. (C) 1997 by John Wiley & Sons, Ltd.