Pr. Smith et al., THE MITOCHONDRIAL TRNA(LEU(UUR))A TO G-3243 MUTATION IS ASSOCIATED WITH INSULIN-DEPENDENT AND NON-INSULIN-DEPENDENT DIABETES IN A CHINESE POPULATION, Diabetic medicine, 14(12), 1997, pp. 1026-1031
The mitochondrial DNA tRNA(Leu(UUR)) A to G 3243 mutation is associate
d with maternally inherited diabetes in Caucasians and Japanese. In a
Hong Kong Chinese population we have detected the 3243 mutation in 2 o
f 74 unrelated subjects with well characterized insulin-dependent (Typ
e 1) diabetes mellitus (IDDM) and 2 of 75 unrelated subjects with youn
g onset (<35 years) non-insulin-dependent diabetes (NIDDM). The 3243 m
utation has only previously been associated with IDDM in Japanese. Rac
ial differences in association of the mitochondrial 3243 mutation with
IDDM suggest the influence of other genes that may increase its diabe
togenic pathogenicity in Oriental races. We also found a significant e
xcess of maternal inheritance of diabetes in the young onset NIDDM coh
ort, with a ratio of diabetic mothers to fathers of 2.4:1, p< 0.005. T
he 3243 mutation, however, only accounts for a small proportion of the
observed excess maternal inheritance, and further study is needed to
search for other diabetes associated mitochondrial DNA mutations. (C)
1997 by John Wiley & Sons, Ltd.