EFFECTS OF APAFANT ON PAF-INDUCED DOWN-REGULATION OF BETA-ADRENOCEPTORS IN GUINEA-PIGS

Authors
SUGIMOTO Y NAKAYAMA Y KISHIDA H HAYAKAWA T FUJIWARA R KAMEI C
Citation
Y. Sugimoto et al., EFFECTS OF APAFANT ON PAF-INDUCED DOWN-REGULATION OF BETA-ADRENOCEPTORS IN GUINEA-PIGS, Methods and findings in experimental and clinical pharmacology, 19(8), 1997, pp. 547-552
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
19
Issue
8
Year of publication
1997
Pages
547 - 552
Database
ISI
SICI code
0379-0355(1997)19:8<547:EOAOPD>2.0.ZU;2-Z
Abstract
We examined the effects of platelet-activating factor (PAF) on beta-ad renoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guine a pig lung parenchymal strips induced by the beta-adrenoceptor agonist , isoproterenol. In addition, PAF decreased the density of beta-adreno ceptors in guinea pig lung without any change in the affinity. Apafant , a potent PAF antagonist, inhibited the above changes, indicating tha t it inhibited the downregulation of beta-adrenoceptors. These finding s suggest that apafant may be effective in nonspecific airway hyperrea ctivity in asthma.