POLY(ALLYLAMMONIUM ACRYLATE) AS A DRUG-RELEASING MATRIX II - RELEASE OF DRUGS ENTRAPPED INTO THE POLYSALT STRUCTURE

The release of drugs, entrapped into the poly(allylammonium acrylate) (PAAC) polyelectrolyte complex structure, was tested for vitamin B-12 (VitB12) and tetracycline (TCY). The PAAC-drug ''composites'' were obt ained by synthesizing PAAC in the presence of either VitB12 or TCY. We ighed samples of the ''composites'' were sintered as tablets, which we re dipped into Dulbecco's PBS (pH 7.3); the release was followed spect rophotometrically. The tests show very low limiting release values, wi th different kinetic behaviours for TCY and VitB12. The results are di scussed and attributed to strong ionic interactions between the polyel ectrolyte complex and the dipolar ions VitB12 and TCY.