Mh. Greisen et al., REDUCTION OF NEUROPEPTIDE-Y BINDING-SITES IN THE RAT HIPPOCAMPUS AFTER ELECTROCONVULSIVE STIMULATIONS, Brain research, 776(1-2), 1997, pp. 105-110
Repetitive electroconvulsive stimulations (ECSs) increase neuropeptide
Y (NPY) synthesis in hippocampal neurons, but whether NPY release and
the density of NPY receptors are affected is unknown. In rats exposed
to 14 daily ECSs, the concentration of NPY specific binding sites in
hippocampal membranes was reduced by about 75% compared with sham, but
was unchanged in membranes isolated from the cerebral cortex and the
thalamus. In accordance with this, in vitro autoradiography revealed a
similar reduction in binding in the dentate gyrus and the CA1 and CA3
regions, but not in the parietal cortex, the entorhinal cortex or the
thalamus. These results show significant changes in NPY receptor bind
ing after repeated ECSs, suggesting that NPYergic neurotransmission, m
ost likely within the hippocampus, is strongly affected by ECSs. (C) 1
997 Elsevier Science B.V.