OBJECTIVE:To determine whether persons living with HIV find a disease-
specific advance directive more acceptable than a generic directive. D
ESIGN: Randomized clinical trial. SETTING: HIV consumer organization a
nd hospital-based HIV clinic. PARTICIPANTS: Volunteer sample of person
s with HIV. INTERVENTIONS:The disease-specific HIV Living Will, the ge
neric Centre for Bioethics Living Will, or both. MEASUREMENTS AND MAIN
RESULTS: Of 101 participants who received both advance directives, 78
(77.2%) preferred the disease-specific HIV Living Will and 23 (22.8%)
preferred the generic Centre for Bioethics Living Will (p < .001). Mo
st participants who preferred the HIV Living Will did so because it wa
s more specific or relevant to their situation. CONCLUSIONS: Persons L
iving with HIV prefer a disease-specific to a generic advance directiv
e. They should be offered a disease-specific advance directive. Our fi
ndings should also encourage investigators to develop and evaluate dis
ease-specific advance directives in other clinical settings.