MUCOSALLY TRANSMITTED FELINE IMMUNODEFICIENCY VIRUS INDUCES A CD8(-ASSOCIATED VIRUS() ANTIVIRAL RESPONSE THAT CORRELATES WITH REDUCTION OF CELL)

Citation
Jg. Bucci et al., MUCOSALLY TRANSMITTED FELINE IMMUNODEFICIENCY VIRUS INDUCES A CD8(-ASSOCIATED VIRUS() ANTIVIRAL RESPONSE THAT CORRELATES WITH REDUCTION OF CELL), The Journal of infectious diseases, 177(1), 1998, pp. 18-25
Citations number
31
Categorie Soggetti
Infectious Diseases
ISSN journal
00221899
Volume
177
Issue
1
Year of publication
1998
Pages
18 - 25
Database
ISI
SICI code
0022-1899(1998)177:1<18:MTFIVI>2.0.ZU;2-7
Abstract
Intravaginal inoculation of cats with feline immunodeficiency virus (F IV) results in acute systemic infection accompanied by a strong CD8(+) immune response that inhibits viral replication, CD8(+) anti-FIV acti vity, revealed by increased FIV replication in peripheral blood mononu clear cells (PBMC) depleted of CD8(+) lymphocytes, was detected by 6 w eeks after inoculation and correlated with reduced PBMC-associated vir us at 12, 16, and 32 weeks after inoculation, Some cats with strong CD 8(+) anti-FIV activity during acute infection did not seroconvert and yielded no evidence of FIV infection at later times, These data sugges t that CD8(+) immunity may play a major role in eliminating virus duri ng primary transmucosal FIV infection and may down-regulate viral repl ication during asymptomatic infection.