HUMAN TUMOR-ANTIGENS RECOGNIZED BY T-CELLS

T-cells play an important role in in vivo tumor rejection in many anim al tumor models and in human melanoma. Many human tumor antigens recog nized by autologous T-cells have now been identified. These are found to be nonmutated and mutated peptides derived from various self protei ns as well as viral proteins. A variety of mechanisms involved in gene rating these T-cell epitopes on growing cancers have also been identif ied. However, the role of these identified antigens remains to be eval uated. Passive or active immunotherapies using these identified tumor antigens are being conducted in many institutions. The results obtaine d from these clinical trials may give us better insight into the role of T-cell responses to each antigen in tumor rejection as well as the development of new antigen-specific immunotherapies for patients with cancer.