Researchers throughout the United States have developed an increased i
nterest in recruiting minority groups into studies. Such increased int
erests have been encouraged by the federal agencies that have mandated
diversity in study populations. This editorial attempts to explore sa
lient issues pertinent to the recruitment and retention of African Ame
ricans and cites culturally specific recruitment strategies that have
been successfully applied by investigators. African Americans may have
special concerns that may have to be addressed by the investigators p
rior to initiation of the study. Concerns may include the fear of bein
g treated as a 'guinea pig' and the need for psychosocial programs, Su
ch concerns require culturally sensitive strategies which may include
trust-building and the provision of ancillary services, Although speci
fic strategies are required to recruit and retain this special populat
ion in clinical studies, there are no guarantees that enrollment will
be successful even with the inclusion of culturally sensitive mechanis
ms.