CYSTIC PULMONARY METASTASES OF ENDOMETRIAL STROMAL SARCOMA OF THE UTERUS, MIMICKING LYMPHANGIOMYOMATOSIS - A CASE-REPORT WITH IMMUNOHISTOCHEMISTRY OF HMB45

Citation
T. Itoh et al., CYSTIC PULMONARY METASTASES OF ENDOMETRIAL STROMAL SARCOMA OF THE UTERUS, MIMICKING LYMPHANGIOMYOMATOSIS - A CASE-REPORT WITH IMMUNOHISTOCHEMISTRY OF HMB45, Pathology international, 47(10), 1997, pp. 725-729
Citations number
16
Journal title
ISSN journal
13205463
Volume
47
Issue
10
Year of publication
1997
Pages
725 - 729
Database
ISI
SICI code
1320-5463(1997)47:10<725:CPMOES>2.0.ZU;2-K
Abstract
A case of endometrial stromal sarcoma (ESS) showed cystic pulmonary me tastases mimicking lymphangiomyomatosis (LAM). A 58-year-old female, w ho had undergone total hysterectomy for low-grade ESS 16 years previou sly, had repeated bouts of pneumothorax. Multiple thin-walled cysts in the peripheral lung were revealed by radiological examinations. In an open-lung biopsy specimen, cystic lesions were surrounded by layers o f spindle-shaped cells of varying thickness that resembled LAM, Howeve r, in addition to subtle histologic differences from LAM, HMB45 (antim elanoma antibody) showed positive in LAM (n=3), but was negative in ES S (n=2) and the cystic lesions of this case, Using myogenic markers (d esmin and alpha-smooth muscle actin), metastatic ESS could be immunohi stochemically differentiated from mesenchymal cystic hamartoma (n=1). HMB45 immunohistochemistry is useful in the differential diagnosis of cystic pulmonary lesions.