In this paper we compare a semi-automated delineation method with tota
lly manual delineation for area quantification, with respect to effici
ency, quality, and intra- and interobserver variability. Liver lesions
on 28 CT images were delineated by three observers, twice using compl
etely manual delineation and twice using a semi-automated method. Quan
titative comparisons were performed with respect to delineated area an
d time required for the delineation tasks. Subjective comparisons were
performed with respect to efficiency and perceived quality of the sem
i-automated method. The areas obtained using semi-automated delineatio
n were significantly smaller (11%) than those obtained using totally m
anual delineation. Intraobserver and interobserver variability with th
e semi-automated method were approximately three times lower than with
manual delineation. Efficiency of the semi-automated method was subje
ctively rated favorable, although further improvements are possible. W
ith respect to quality, the semi-automated method was ranked better th
an the manual method in 73% of cases.