UNDIFFERENTIATED CARCINOMA OF NASOPHARYNGEAL TYPE OF THE LARYNGOPHARYNGEAL REGION

Undifferentiated carcinoma of nasopharyngeal type (lymphoepithelioma) is an extremely rare malignancy in the laryngohypopharyngeal region, W e found reports of only 13 such tumors in the English language literat ure, We present the findings of four additional cases, one hypopharyng eal and three laryngeal in origin. The three laryngeal tumors were cha racterized by submucosal spread, The tumors were classified T3 (2x) an d T4 (2x) with cervical lymph node metastases at initial presentation in all cases, In three of our tour cases the Epstein-Barr virus was de monstrated by the Epstein-Barr virus-encoded RNAs in situ hybridizatio n.